Lymphatic Cyst Eye - Things You Didnt Know

Organ organisation in vertebrates

The lymphatic organization, or lymphoid system, is an organ organization in vertebrates that is part of the immune system, and complementary to the circulatory organisation. Information technology comprises of a large network of lymphatic vessels, lymph nodes, lymphatic or lymphoid organs, and lymphoid tissues.^{[1] [two]} The vessels carry a clear fluid chosen lymph (the Latin word lympha refers to the deity of fresh water, "Lympha")^[3] back towards the heart, for re-circulation.

Unlike the circulatory system that is a closed system, the lymphatic organisation is open. The homo circulatory system processes an boilerplate of 20 litres of claret per twenty-four hour period through capillary filtration, which removes plasma from the blood. Roughly 17 litres of the filtered blood is reabsorbed directly into the blood vessels, while the remaining three litres are left in the interstitial fluid. Ane of the main functions of the lymphatic system is to provide an accessory return route to the blood for the surplus 3 litres.^[4]

The other master function is that of allowed defense. Lymph is very like to blood plasma, in that it contains waste products and cellular debris, together with bacteria and proteins. The cells of the lymph are mostly lymphocytes. Associated lymphoid organs are composed of lymphoid tissue, and are the sites either of lymphocyte product or of lymphocyte activation. These include the lymph nodes (where the highest lymphocyte concentration is found), the spleen, the thymus, and the tonsils. Lymphocytes are initially generated in the bone marrow. The lymphoid organs also contain other types of cells such as stromal cells for support.^[5] Lymphoid tissue is also associated with mucosas such as mucosa-associated lymphoid tissue (MALT).^[6]

Fluid from circulating blood leaks into the tissues of the trunk past capillary action, carrying nutrients to the cells. The fluid bathes the tissues as interstitial fluid, collecting waste products, bacteria, and damaged cells, and so drains every bit lymph into the lymphatic capillaries and lymphatic vessels. These vessels comport the lymph throughout the trunk, passing through numerous lymph nodes which filter out unwanted materials such equally bacteria and damaged cells. Lymph and then passes into much larger lymph vessels known as lymph ducts. The right lymphatic duct drains the right side of the region and the much larger left lymphatic duct, known as the thoracic duct, drains the left side of the body. The ducts empty into the subclavian veins to return to the blood circulation. Lymph is moved through the organisation by muscle contractions.^[seven] In some vertebrates, a lymph middle is present that pumps the lymph to the veins.^{[vii] [8]}

The lymphatic system was start described in the 17th century independently by Olaus Rudbeck and Thomas Bartholin.^[nine]

Structure

Diagram of vessels and organs in the lymphatic system

The lymphatic system consists of a conducting network of lymphatic vessels, lymphoid organs, lymphoid tissues, and the circulating lymph.

Primary lymphoid organs

The primary (or cardinal) lymphoid organs generate lymphocytes from immature progenitor cells. The thymus and the bone marrow plant the primary lymphoid organs involved in the production and early on clonal selection of lymphocyte tissues.

Bone marrow

Os marrow is responsible for both the creation of T cell precursors and the production and maturation of B cells, which are important prison cell types of the immune system. From the bone marrow, B cells immediately bring together the circulatory system and travel to secondary lymphoid organs in search of pathogens. T cells, on the other hand, travel from the os marrow to the thymus, where they develop farther and mature. Mature T cells and then join B cells in search of pathogens. The other 95% of T cells brainstorm a process of apoptosis, a grade of programmed cell death.

Thymus

The thymus increases in size from nascence in response to postnatal antigen stimulation. Information technology is most active during the neonatal and pre-adolescent periods. At puberty, past the early on teens, the thymus begins to atrophy and regress, with adipose tissue more often than not replacing the thymic stroma. However, residue T lymphopoiesis continues throughout adult life. The loss or lack of the thymus results in severe immunodeficiency and subsequent high susceptibility to infection. In well-nigh species, the thymus consists of lobules divided by septa which are made up of epithelium; information technology is therefore often considered an epithelial organ. T cells mature from thymocytes, proliferate, and undergo a selection procedure in the thymic cortex earlier entering the medulla to interact with epithelial cells.

The thymus provides an inductive environment for the evolution of T cells from hematopoietic progenitor cells. In addition, thymic stromal cells allow for the choice of a functional and self-tolerant T cell repertoire. Therefore, i of the most important roles of the thymus is the induction of central tolerance.

Secondary lymphoid organs

The secondary (or peripheral) lymphoid organs (SLO), which include lymph nodes and the spleen, maintain mature naive lymphocytes and initiate an adaptive immune response.^[10] The secondary lymphoid organs are the sites of lymphocyte activation past antigens. Activation leads to clonal expansion and affinity maturation. Mature lymphocytes recirculate between the blood and the secondary lymphoid organs until they encounter their specific antigen.

Spleen

The main functions of the spleen are:

1. to produce immune cells to fight antigens
2. to remove particulate matter and aged blood cells, mainly red blood cells
3. to produce claret cells during fetal life.

The spleen synthesizes antibodies in its white pulp and removes antibody-coated leaner and antibiotic-coated blood cells by way of blood and lymph node apportionment. A study published in 2009 using mice constitute that the spleen contains, in its reserve, half of the body'south monocytes inside the cherry pulp.^[11] These monocytes, upon moving to injured tissue (such as the center), turn into dendritic cells and macrophages while promoting tissue healing.^{[11] [12] [13]} The spleen is a middle of activity of the mononuclear phagocyte organization and can be considered coordinating to a large lymph node, as its absenteeism causes a predisposition to certain infections.

Like the thymus, the spleen has but efferent lymphatic vessels. Both the curt gastric arteries and the splenic artery supply it with blood.^[14] The germinal centers are supplied by arterioles called penicilliary radicles.^[15]

Until the fifth month of prenatal development, the spleen creates red blood cells; after birth, the bone marrow is solely responsible for hematopoiesis. As a major lymphoid organ and a cardinal player in the reticuloendothelial system, the spleen retains the power to produce lymphocytes. The spleen stores reddish claret cells and lymphocytes. It tin can shop enough blood cells to help in an emergency. Up to 25% of lymphocytes can be stored at any one time.^[xvi]

Lymph nodes

Regional lymph nodes

A lymph node is an organized collection of lymphoid tissue, through which the lymph passes on its way back to the blood. Lymph nodes are located at intervals along the lymphatic system. Several afferent lymph vessels bring in lymph, which percolates through the substance of the lymph node, and is then drained out by an efferent lymph vessel. Of the nearly 800 lymph nodes in the human torso, about 300 are located in the caput and neck.^[17] Many are grouped in clusters in different regions, equally in the underarm and abdominal areas. Lymph node clusters are ordinarily found at the proximal ends of limbs (groin, armpits) and in the neck, where lymph is collected from regions of the torso likely to sustain pathogen contamination from injuries. Lymph nodes are particularly numerous in the mediastinum in the chest, neck, pelvis, axilla, inguinal region, and in association with the blood vessels of the intestines.^[6]

The substance of a lymph node consists of lymphoid follicles in an outer portion called the cortex. The inner portion of the node is chosen the medulla, which is surrounded past the cortex on all sides except for a portion known as the hilum. The hilum presents every bit a low on the surface of the lymph node, causing the otherwise spherical lymph node to be edible bean-shaped or ovoid. The efferent lymph vessel directly emerges from the lymph node at the hilum. The arteries and veins supplying the lymph node with blood enter and leave through the hilum. The region of the lymph node called the paracortex immediately surrounds the medulla. Dissimilar the cortex, which has mostly immature T cells, or thymocytes, the paracortex has a mixture of young and mature T cells. Lymphocytes enter the lymph nodes through specialised high endothelial venules found in the paracortex.

A lymph follicle is a dumbo drove of lymphocytes, the number, size, and configuration of which change in accordance with the functional land of the lymph node. For example, the follicles aggrandize significantly when encountering a strange antigen. The pick of B cells, or B lymphocytes, occurs in the germinal centre of the lymph nodes.

Secondary lymphoid tissue provides the environment for the foreign or altered native molecules (antigens) to collaborate with the lymphocytes. It is exemplified past the lymph nodes, and the lymphoid follicles in tonsils, Peyer's patches, spleen, adenoids, skin, etc. that are associated with the mucosa-associated lymphoid tissue (MALT).

In the gastrointestinal wall, the appendix has mucosa resembling that of the colon, but here it is heavily infiltrated with lymphocytes.

Tertiary lymphoid organs

Third lymphoid organs (TLOs) are abnormal lymph node-like structures that form in peripheral tissues at sites of chronic inflammation, such as chronic infection, transplanted organs undergoing graft rejection, some cancers, and autoimmune and autoimmune-related diseases.^[18] TLOs are regulated differently from the normal process whereby lymphoid tissues are formed during ontogenesis, being dependent on cytokines and hematopoietic cells, only still bleed interstitial fluid and transport lymphocytes in response to the aforementioned chemical messengers and gradients.^[xix] TLOs typically contain far fewer lymphocytes, and presume an allowed part only when challenged with antigens that result in inflammation. They attain this by importing the lymphocytes from blood and lymph.^[20] TLOs frequently accept an active germinal center, surrounded past a network of follicular dendritic cells (FDCs).^[21]

TLOs are thought to play an of import role in the immune response to cancer and to have possible implications in immunotherapy. They have been observed in a number of cancer types such every bit melanoma, non-small jail cell lung cancer and colorectal cancer (reviewed in ^[22]) as well equally glioma.^[23] Patients with TLOs in the vicinity of their tumors tend to take a better prognosis,^{[24] [25]} although the opposite is true for sure cancers.^[26] TLOs that incorporate an active germinal center tend to have a better prognosis than those with TLOs without a germinal center.^{[24] [25]} The reason that these patients tend to alive longer is idea to be the immune response against the tumor, which is mediated by the TLOs. TLOs may also promote an anti-tumor response when patients are treated with immunotherapy.^[27] TLOs have been referred to in many dissimilar ways, including as tertiary lymphoid structures (TLS) and ectopic lymphoid structures (ELS). When associated with colorectal cancer, they are ofttimes referred to as a Crohn'south-similar lymphoid reaction.^[24]

Other lymphoid tissue

Lymphoid tissue associated with the lymphatic system is concerned with allowed functions in defending the body confronting infections and the spread of tumours. It consists of connective tissue formed of reticular fibers, with various types of leukocytes (white blood cells), generally lymphocytes enmeshed in information technology, through which the lymph passes.^[28] Regions of the lymphoid tissue that are densely packed with lymphocytes are known as lymphoid follicles. Lymphoid tissue can either be structurally well organized as lymph nodes or may consist of loosely organized lymphoid follicles known as the mucosa-associated lymphoid tissue (MALT).

The key nervous system as well has lymphatic vessels. The search for T cell gateways into and out of the meninges uncovered functional meningeal lymphatic vessels lining the dural sinuses, anatomically integrated into the membrane surrounding the brain.^[29]

Lymphatic vessels

Lymph capillaries in the tissue spaces

The lymphatic vessels, too called lymph vessels, are thin-walled vessels that conduct lymph between unlike parts of the trunk.^[30] They include the tubular vessels of the lymph capillaries, and the larger collecting vessels–the right lymphatic duct and the thoracic duct (the left lymphatic duct). The lymph capillaries are mainly responsible for the absorption of interstitial fluid from the tissues, while lymph vessels propel the absorbed fluid forwards into the larger collecting ducts, where information technology ultimately returns to the bloodstream via one of the subclavian veins.

The tissues of the lymphatic system are responsible for maintaining the balance of the body fluids. Its network of capillaries and collecting lymphatic vessels piece of work to efficiently drain and transport extravasated fluid, forth with proteins and antigens, dorsum to the circulatory system. Numerous intraluminal valves in the vessels ensure a unidirectional menstruation of lymph without reflux.^[31] 2 valve systems, a primary and a secondary valve system, are used to achieve this unidirectional period.^[32] The capillaries are blind-ended, and the valves at the ends of capillaries use specialised junctions together with anchoring filaments to permit a unidirectional flow to the primary vessels. The collecting lymphatics, however, human activity to propel the lymph by the combined actions of the intraluminal valves and lymphatic muscle cells.^[33]

Evolution

Lymphatic tissues begin to develop by the stop of the fifth week of embryonic development.

Lymphatic vessels develop from lymph sacs that arise from developing veins, which are derived from mesoderm.

The showtime lymph sacs to appear are the paired jugular lymph sacs at the junction of the internal jugular and subclavian veins.

From the jugular lymph sacs, lymphatic capillary plexuses spread to the thorax, upper limbs, cervix, and head.

Some of the plexuses enlarge and form lymphatic vessels in their respective regions. Each jugular lymph sac retains at least one connexion with its jugular vein, the left one developing into the superior portion of the thoracic duct.

The spleen develops from mesenchymal cells between layers of the dorsal mesentery of the stomach.

The thymus arises as an outgrowth of the third pharyngeal pouch.

Function

The lymphatic organization has multiple interrelated functions:^[34]

• Information technology is responsible for the removal of interstitial fluid from tissues
• It absorbs and transports fat acids and fats as chyle from the digestive system
• It transports white claret cells to and from the lymph nodes into the bones
• The lymph transports antigen-presenting cells, such every bit dendritic cells, to the lymph nodes where an immune response is stimulated.

Fat absorption

Nutrients in nutrient are absorbed via abdominal vili (greatly enlarged in the picture) to blood and lymph. Long-chain fatty acids (and other lipids with similar fatty solubility like some medicines) are captivated to the lymph and move in it enveloped within chylomicrons. They move via the thoracic duct of the lymphatic arrangement and finally enter the blood via the left subclavian vein, thus bypassing the liver'due south first-laissez passer metabolism completely.

Lymph vessels chosen lacteals are at the beginning of the gastrointestinal tract, predominantly in the pocket-size intestine. While near other nutrients absorbed past the pocket-size intestine are passed on to the portal venous system to drain via the portal vein into the liver for processing, fats (lipids) are passed on to the lymphatic organization to exist transported to the blood circulation via the thoracic duct. (There are exceptions, for example medium-concatenation triglycerides are fatty acid esters of glycerol that passively lengthened from the GI tract to the portal arrangement.) The enriched lymph originating in the lymphatics of the small intestine is called chyle. The nutrients that are released into the circulatory arrangement are processed by the liver, having passed through the systemic apportionment.

Allowed function

-The lymphatic system plays a major role in the body'south immune system, as the primary site for cells relating to adaptive immune system including T-cells and B-cells.

Cells in the lymphatic system react to antigens presented or found by the cells directly or by other dendritic cells.

When an antigen is recognized, an immunological cascade begins involving the activation and recruitment of more than and more cells, the production of antibodies and cytokines and the recruitment of other immunological cells such as macrophages.

Clinical significance

The study of lymphatic drainage of diverse organs is important in the diagnosis, prognosis, and handling of cancer. The lymphatic arrangement, because of its closeness to many tissues of the body, is responsible for carrying cancerous cells between the various parts of the body in a process chosen metastasis. The intervening lymph nodes tin can trap the cancer cells. If they are not successful in destroying the cancer cells the nodes may become sites of secondary tumours.

Enlarged lymph nodes

Lymphadenopathy refers to one or more enlarged lymph nodes. Small-scale groups or individually enlarged lymph nodes are more often than not reactive in response to infection or inflammation. This is called local lymphadenopathy. When many lymph nodes in different areas of the body are involved, this is called generalised lymphadenopathy. Generalised lymphadenopathy may be caused by infections such as infectious mononucleosis, tuberculosis and HIV, connective tissue diseases such as SLE and rheumatoid arthritis, and cancers, including both cancers of tissue inside lymph nodes, discussed beneath, and metastasis of cancerous cells from other parts of the trunk, that have arrived via the lymphatic system.^[35]

Lymphedema

Lymphedema is the swelling caused by the accumulation of lymph, which may occur if the lymphatic system is damaged or has malformations. It usually affects limbs, though the confront, neck and abdomen may likewise be affected. In an extreme country, called elephantiasis, the edema progresses to the extent that the pare becomes thick with an appearance similar to the skin on elephant limbs.^[36]

Causes are unknown in nearly cases, but sometimes there is a previous history of astringent infection, usually caused by a parasitic disease, such every bit lymphatic filariasis.

Lymphangiomatosis is a illness involving multiple cysts or lesions formed from lymphatic vessels.^{[ relevant to this paragraph? – hash out ]}

Lymphedema tin likewise occur after surgical removal of lymph nodes in the armpit (causing the arm to swell due to poor lymphatic drainage) or groin (causing swelling of the leg). Conventional treatment is by manual lymphatic drainage and compression garments. Two drugs for the handling of lymphedema are in clinical trials: Lymfactin^[37] and Ubenimex/Bestatin.

There is no evidence to suggest that the effects of manual lymphatic drainage are permanent.^[38]

Cancer

Cancer of the lymphatic system can be primary or secondary. Lymphoma refers to cancer that arises from lymphatic tissue. Lymphoid leukaemias and lymphomas are now considered to be tumours of the same type of jail cell lineage. They are chosen "leukaemia" when in the blood or marrow and "lymphoma" when in lymphatic tissue. They are grouped together under the name "lymphoid malignancy".^[39]

Lymphoma is by and large considered equally either Hodgkin lymphoma or non-Hodgkin lymphoma. Hodgkin lymphoma is characterised past a particular type of jail cell, called a Reed–Sternberg cell, visible under microscope. It is associated with by infection with the Epstein–Barr virus, and generally causes a painless "rubbery" lymphadenopathy. Information technology is staged, using Ann Arbor staging. Chemotherapy generally involves the ABVD and may also involve radiotherapy.^[35] Not-Hodgkin lymphoma is a cancer characterised by increased proliferation of B-cells or T-cells, more often than not occurs in an older historic period group than Hodgkin lymphoma. It is treated co-ordinate to whether it is high-grade or low-grade, and carries a poorer prognosis than Hodgkin lymphoma.^[35]

Lymphangiosarcoma is a malignant soft tissue tumour, whereas lymphangioma is a benign neoplasm occurring oftentimes in association with Turner syndrome. Lymphangioleiomyomatosis is a benign neoplasm of the polish muscles of the lymphatics that occurs in the lungs.

Lymphoid leukaemia is another form of cancer where the host is devoid of different lymphatic cells.

Other

• Castleman'southward affliction
• Chylothorax
• Kawasaki affliction
• Kikuchi affliction
• Lipedema
• Lymphangitis
• Lymphatic filariasis
• Lymphocytic choriomeningitis
• Lonely lymphatic nodule

History

Hippocrates, in the 5th century BC, was one of the offset people to mention the lymphatic arrangement. In his piece of work On Joints, he briefly mentioned the lymph nodes in one judgement. Rufus of Ephesus, a Roman physician, identified the axillary, inguinal and mesenteric lymph nodes likewise as the thymus during the 1st to 2nd century Advert.^[twoscore] The offset mention of lymphatic vessels was in the tertiary century BC past Herophilos, a Greek anatomist living in Alexandria, who incorrectly concluded that the "absorptive veins of the lymphatics," by which he meant the lacteals (lymph vessels of the intestines), drained into the hepatic portal veins, and thus into the liver.^[40] The findings of Ruphus and Herophilos were farther propagated by the Greek physician Galen, who described the lacteals and mesenteric lymph nodes which he observed in his dissection of apes and pigs in the second century AD.^[40]

In the mid 16th century, Gabriele Falloppio (discoverer of the fallopian tubes), described what is now known equally the lacteals as "coursing over the intestines full of xanthous thing."^[40] In about 1563 Bartolomeo Eustachi, a professor of anatomy, described the thoracic duct in horses every bit vena alba thoracis. ^[twoscore] The next quantum came when in 1622 a physician, Gaspare Aselli, identified lymphatic vessels of the intestines in dogs and termed them venae albae et lacteae, which are at present known as but the lacteals. The lacteals were termed the fourth kind of vessels (the other three being the avenue, vein and nerve, which was then believed to be a blazon of vessel), and disproved Galen's assertion that chyle was carried by the veins. Simply, he all the same believed that the lacteals carried the chyle to the liver (as taught by Galen).^[41] He also identified the thoracic duct just failed to observe its connectedness with the lacteals.^[40] This connection was established by Jean Pecquet in 1651, who institute a white fluid mixing with blood in a dog's heart. He suspected that fluid to exist chyle as its flow increased when abdominal force per unit area was applied. He traced this fluid to the thoracic duct, which he and then followed to a chyle-filled sac he called the chyli receptaculum, which is now known as the cisternae chyli; further investigations led him to find that lacteals' contents enter the venous organization via the thoracic duct.^{[40] [41]} Thus, it was proven assuredly that the lacteals did non terminate in the liver, thus disproving Galen'southward second idea: that the chyle flowed to the liver.^[41] Johann Veslingius drew the earliest sketches of the lacteals in humans in 1647.^{[ citation needed ]}

The thought that blood recirculates through the torso rather than existence produced anew by the liver and the heart was first accepted equally a effect of works of William Harvey—a work he published in 1628. In 1652, Olaus Rudbeck (1630–1702), a Swede, discovered certain transparent vessels in the liver that contained clear fluid (and not white), and thus named them hepatico-aqueous vessels. He likewise learned that they emptied into the thoracic duct and that they had valves.^[41] He announced his findings in the court of Queen Christina of Sweden, but did not publish his findings for a yr,^[42] and in the interim similar findings were published past Thomas Bartholin, who additionally published that such vessels are nowadays everywhere in the body, non only in the liver. He is likewise the ane to have named them "lymphatic vessels."^[41] This had resulted in a bitter dispute betwixt one of Bartholin'due south pupils, Martin Bogdan,^[43] and Rudbeck, whom he accused of plagiarism.^[42]

Galen'south ideas prevailed in medicine until the 17th century. It was thought that claret was produced by the liver from chyle contaminated with ailments past the intestine and tummy, to which various spirits were added by other organs, and that this blood was consumed by all the organs of the body. This theory required that the blood be consumed and produced many times over. Fifty-fifty in the 17th century, his ideas were defended past some physicians.^{[ citation needed ]}

Alexander Monro, of the Academy of Edinburgh Medical School, was the first to draw the part of the lymphatic system in detail.^[44]

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  "Claude Galien". Lithograph past Pierre Roche Vigneron. (Paris: Lith de Gregoire et Deneux, ca. 1865)

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Etymology

Lymph originates in the Classical Latin discussion lympha "h2o",^[45] which is likewise the source of the English give-and-take limpid. The spelling with y and ph was influenced by folk etymology with Greek νύμϕη ( nýmphē ) "nymph".^[46]

The adjective used for the lymph-transporting arrangement is lymphatic. The adjective used for the tissues where lymphocytes are formed is lymphoid. Lymphatic comes from the Latin word lymphaticus , meaning "connected to h2o."

Run across also

• Listing of lymphatic vessels of the human body
• American Society of Lymphology
• Glymphatic organisation and Meningeal lymphatic vessels - equivalent for the central nervous system
• Innate lymphoid cells
• Lymphangiogenesis
• Lymphangion
• Mononuclear phagocyte system
• Waldemar Olszewski – discovered fundamental processes in human tissues connected with function of the lymphatic organization
• Trogocytosis

References

1. ^ Standring S (2016). Greyness's anatomy : the anatomical basis of clinical practice (Forty-first ed.). pp. 68–73. ISBN9780702052309.
2. ^ Moore K (2018). Clinically oriented beefcake (8th ed.). pp. 43–45. ISBN9781496347213.
3. ^ Natale G, Bocci G, Ribatti D (September 2017). "Scholars and scientists in the history of the lymphatic system". Journal of Anatomy. 231 (iii): 417–429. doi:10.1111/joa.12644. PMC5554832. PMID 28614587.
4. ^ Sherwood L (Jan one, 2012). Human Physiology: From Cells to Systems. Cengage Learning. ISBN9781111577438 – via Google Books.
5. ^
6. ^ ^{a b} Warwick R, Williams PL. "Angiology (Chapter vi)". Gray's anatomy (30-fifth ed.). London: Longman. pp. 588–785.
7. ^ ^{a b} Peyrot SM, Martin BL, Harland RM (March 2010). "Lymph heart musculature is under distinct developmental command from lymphatic endothelium". Developmental Biology. 339 (2): 429–38. doi:ten.1016/j.ydbio.2010.01.002. PMC2845526. PMID 20067786.
8. ^ Jeltsch M, Tammela T, Alitalo K, Wilting J (October 2003). "Genesis and pathogenesis of lymphatic vessels". Prison cell and Tissue Research. 314 (1): 69–84. doi:10.1007/s00441-003-0777-ii. PMID 12942362. S2CID 23318096.
9. ^ Eriksson G (2004). "[Olaus Rudbeck as scientist and professor of medicine]". Svensk Medicinhistorisk Tidskrift. 8 (ane): 39–44. PMID 16025602.
10. ^ Ruddle NH, Akirav EM (Baronial 2009). "Secondary lymphoid organs: responding to genetic and environmental cues in ontogenesis and the allowed response". Periodical of Immunology. 183 (four): 2205–12. doi:ten.4049/jimmunol.0804324. PMC2766168. PMID 19661265.
11. ^ ^{a b} Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber 1000, Cortez-Retamozo 5, Panizzi P, et al. (July 2009). "Identification of splenic reservoir monocytes and their deployment to inflammatory sites". Science. 325 (5940): 612–6. Bibcode:2009Sci...325..612S. doi:ten.1126/science.1175202. PMC2803111. PMID 19644120.
12. ^ Jia T, Pamer EG (July 2009). "Immunology. Dispensable but not irrelevant". Science. 325 (5940): 549–50. Bibcode:2009Sci...325..549J. doi:ten.1126/science.1178329. PMC2917045. PMID 19644100.
13. ^ Angier Northward (August iii, 2009). "Finally, the Spleen Gets Some Respect". The New York Times. Archived from the original on 2018-01-27.
14. ^ Blackbourne LH (2008-04-01). Surgical recall. Lippincott Williams & Wilkins. p. 259. ISBN978-0-7817-7076-7.
15. ^ "Penicilliary radicles". Saunders Comprehensive Veterinarian Dictionary (3rd ed.). Elsevier, Inc. 2007. Archived from the original on 2016-03-04. Retrieved 2011-04-03 – via The Complimentary Dictionary by Farlex.
16. ^ "Spleen: Information, Surgery and Functions". Childrens Hospital of Pittsburgh - Chp.edu. 2010-eleven-17. Archived from the original on 2011-09-26. Retrieved 2011-04-03 .
17. ^ Singh V (2017). Textbook of Anatomy Head, Neck, and Brain; Volume Iii (2d ed.). pp. 247–249. ISBN9788131237274.
18. ^ Yin C, Mohanta S, Maffia P, Habenicht AJ (6 March 2017). "Editorial: Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity". Frontiers in Immunology. 8: 228. doi:10.3389/fimmu.2017.00228. PMC5337484. PMID 28321222.
19. ^ Ruddle NH (March 2014). "Lymphatic vessels and third lymphoid organs". The Journal of Clinical Investigation. 124 (3): 953–9. doi:10.1172/JCI71611. PMC3934190. PMID 24590281.
20. ^ Goldsby R, Kindt TJ, Osborne BA, Janis K (2003) [1992]. "Cells and Organs of the Allowed Arrangement (Chapter 2)". Immunology (Fifth ed.). New York: Due west. H. Freeman and Visitor. pp. 24–56. ISBN0-7167-4947-5.
21. ^ Hiraoka Northward, Ino Y, Yamazaki-Itoh R (2016-06-22). "Tertiary Lymphoid Organs in Cancer Tissues". Frontiers in Immunology. 7: 244. doi:10.3389/fimmu.2016.00244. PMC4916185. PMID 27446075.
22. ^ Sautès-Fridman, C; Petitprez, F; Calderaro, J; Fridman, WH (June 2019). "Tertiary lymphoid structures in the era of cancer immunotherapy" (PDF). Nature Reviews. Cancer. xix (6): 307–325. doi:ten.1038/s41568-019-0144-6. PMID 31092904. S2CID 155104003.
23. ^ van Hooren, L; Vaccaro, A; Ramachandran, M; Vazaios, K; Libard, S; van de Walle, T; Georganaki, M; Huang, H; Pietilä, I; Lau, J; Ulvmar, MH; Karlsson, MCI; Zetterling, One thousand; Mangsbo, SM; Jakola, AS; Olsson Bontell, T; Smits, A; Essand, M; Dimberg, A (five July 2021). "Agonistic CD40 therapy induces third lymphoid structures merely impairs responses to checkpoint blockade in glioma". Nature Communications. 12 (1): 4127. doi:10.1038/s41467-021-24347-vii. PMC8257767. PMID 34226552.
24. ^ ^{a b c} Maoz A, Dennis 1000, Greenson JK (2019). "The Crohn's-Like Lymphoid Reaction to Colorectal Cancer-Tertiary Lymphoid Structures With Immunologic and Potentially Therapeutic Relevance in Colorectal Cancer". Frontiers in Immunology. 10: 1884. doi:10.3389/fimmu.2019.01884. PMC6714555. PMID 31507584.
25. ^ ^{a b} Sautès-Fridman C, Petitprez F, Calderaro J, Fridman WH (June 2019). "3rd lymphoid structures in the era of cancer immunotherapy" (PDF). Nature Reviews. Cancer. 19 (half-dozen): 307–325. doi:10.1038/s41568-019-0144-half dozen. PMID 31092904. S2CID 155104003.
26. ^ Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, et al. (December 2015). "Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma". Nature Immunology. 16 (12): 1235–44. doi:10.1038/ni.3290. PMC4653079. PMID 26502405.
27. ^ Helmink BA, Reddy SM, Gao J, Zhang S, Basar R, Thakur R, et al. (January 2020). "B cells and tertiary lymphoid structures promote immunotherapy response" (PDF). Nature. 577 (7791): 549–555. Bibcode:2020Natur.577..549H. doi:10.1038/s41586-019-1922-viii. PMID 31942075. S2CID 210221106.
28. ^ "lymphoid tissue" at Dorland'south Medical Dictionary
29. ^ Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, et al. (July 2015). "Structural and functional features of central nervous system lymphatic vessels". Nature. 523 (7560): 337–41. Bibcode:2015Natur.523..337L. doi:10.1038/nature14432. PMC4506234. PMID 26030524. Lay summary – National Institutes of Health. we discovered functional lymphatic vessels lining the dural sinuses. These structures express all of the molecular hallmarks of lymphatic endothelial cells, are able to conduct both fluid and immune cells from the cerebrospinal fluid, and are connected to the deep cervical lymph nodes. The unique location of these vessels may have impeded their discovery to date, thereby contributing to the long-held concept of the absence of lymphatic vasculature in the key nervous arrangement. The discovery of the cardinal nervous system lymphatic organization may phone call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with allowed system dysfunction.
30. ^ Kumar V (2018). Robbins bones pathology (Tenth ed.). p. 363. ISBN9780323353175.
31. ^ Vittet D (November 2014). "Lymphatic collecting vessel maturation and valve morphogenesis". Microvascular Enquiry. 96: 31–seven. doi:ten.1016/j.mvr.2014.07.001. PMID 25020266.
32. ^ Heppell C, Richardson Grand, Roose T (January 2013). "A model for fluid drainage past the lymphatic system". Bulletin of Mathematical Biology. 75 (1): 49–81. doi:10.1007/s11538-012-9793-2. PMID 23161129. S2CID 20438669.
33. ^ Bazigou E, Wilson JT, Moore JE (Nov 2014). "Principal and secondary lymphatic valve evolution: molecular, functional and mechanical insights". Microvascular Enquiry. 96: 38–45. doi:10.1016/j.mvr.2014.07.008. PMC4490164. PMID 25086182.
34. ^ "The functions of the Lymphatic System". lymphnotes.com . Retrieved Feb 25, 2011.
35. ^ ^{a b c} Colledge NR, Ralston SH, Walker BR, eds. (2011). Davidson's principles and practice of medicine (21st ed.). Edinburgh / New York: Churchill Livingstone / Elsevier. pp. 1001, 1037–1040. ISBN978-0-7020-3085-7. OCLC 844959047.
36. ^ Douketis JD. "Lymphedema". Merck Manual.
37. ^ Herantis Pharma (2015-07-21). "Lymfactin® for lymphedema". Archived from the original on 2018-12-08. Retrieved 2018-12-28 .
38. ^ Martín ML, Hernández MA, Avendaño C, Rodríguez F, Martínez H (March 2011). "Transmission lymphatic drainage therapy in patients with breast cancer related lymphoedema". BMC Cancer. 11 (one): 94. doi:10.1186/1471-2407-11-94. PMC3065438. PMID 21392372.
39. ^ Fauci AS, Braunwald Due east, Kasper D, Hauser S, Longo DL (19 March 2009). Harrison'due south Manual of Medicine. McGraw Hill Professiona. pp. 352–. ISBN978-0-07-147743-7 . Retrieved 12 November 2010.
40. ^ ^{a b c d e f g} Ambrose CT (July 2006). "Immunology's first priority dispute--an account of the 17th-century Rudbeck-Bartholin feud". Cellular Immunology. 242 (ane): 1–8. doi:x.1016/j.cellimm.2006.09.004. PMID 17083923.
41. ^ ^{a b c d e} Flourens P (1859). "Chapter three: Aselli, Pecquet, Rudbeck, Bartholin". A History of the Discovery of the Circulation of the Blood. Rickey, Mallory & company. pp. 67–99. Retrieved 2008-07-11 . william harvey.
42. ^ ^{a b} Eriksson G (2004). "[Olaus Rudbeck as scientist and professor of medicine]". Svensk Medicinhistorisk Tidskrift (in Swedish). 8 (1): 39–44. PMID 16025602.
43. ^ "Disputatio anatomica, de circulatione sanguinis" [Account of Rudbeck's piece of work on lymphatic system and dispute with Bartholin]. International League of Antiquarian Booksellers . Retrieved 2008-07-xi . ^{[ dead link ]}
44. ^ Turner AL (1937). Story of a Bang-up Infirmary: The Royal Infirmary of Edinburgh 1729-1929. Oliver and Boyd. p. 360.
45. ^ lympha. Charlton T. Lewis and Charles Brusk. A Latin Dictionary on Perseus Project.
46. ^ "lymph". Oxford English Dictionary (Online ed.). Oxford University Press. (Subscription or participating institution membership required.)

External links

• Lymphatic Organization
• Lymphatic System Overview (innerbody.com)

This page was last edited on 2 March 2022, at 23:46

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Source: https://wiki2.org/en/Lymphatic_system

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